Abstracts
Résumé
Le facteur de transcription TBP (TATA-binding protein) est une sous-unité de plusieurs complexes macromoléculaires nécessaires à la transcription par les trois ARN polymérases nucléaires. Cette observation avait conduit à faire de TBP un facteur « universel » de la transcription. La dé-couverte de trois protéines apparentées à TBP, et d’un complexe macromoléculaire dépourvu de TBP, mais capable d’initier la transcription par l’ARN polymérase II in vitro, a conduit à remettre en cause le caractère universel de TBP. Plusieurs études in vivo ont montré que TBP a plutôt un rôle specifique dans l’activation de certains gènes impliqués dans la prolifération cellulaire. De plus, le domaine aminoterminal de TBP joue un rôle dans l’établissement de la tolérance foetomaternelle.
Summary
The TATA binding protein (TBP) is a subunit of several macromolecular complexes required for transcription by the three nuclear RNA polymerases. This observation led to the idea that TBP is a « universal » transcription factor. The discovery of three TBP-related factors and a macromolecular complex which lacks TBP but can support RNA polymerase II transcription in vitro has led to a reappraisal of the universal character of TBP. Several in vivo studies have rather shown that TBP plays a specific role in the activation of a subset of cellular genes controlling the cell cycle. In mammals, the aminoterminal region of TBP plays a highly selective role in the maternal immunotolerance of pregnancy.
Appendices
Références
- 1. Albright SR, Tjian R. TAFs revisited : More data reveal new twists and confirm old ideas. Gene 2000 ; 242 : 1-13.
- 2. Gangloff Y, Romier C, Thuault S, et al. The histone fold is a key structural motif of transcription factor TFIID. Trends Biochem Sci 2001 ; 26 : 250-7.
- 3. Timmers HTM, Meyers RE, Sharp PA. Composition of transcription factor B-TFIID. Proc Natl Acad Sci USA 1992 ; 89 : 8140-4.
- 4. van der Knaap JA, Borst JW, van der Vliet PC, et al. Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila. Proc Natl Acad Sci USA 1997 ; 94 : 11827-32.
- 5. Hernandez N. TBP, a universal eukaryotic transcription factor? Genes Dev 1993 ; 7 : 1291-308.
- 6. Burley SK, Roeder RG. Biochemistry and structural biology of transcription factor IID (TFIID). Annu Rev Biochem 1996 ; 65 : 769-99.
- 7. Burley SK. Picking up the TAB. Nature 1996 ; 381 : 112-3.
- 8. Burley SK. X-ray crystallographic studies of eukaryotic transcription initiation factors. Philos Trans R Soc Lond B Biol Sci 1996 ; 351 : 483-9.
- 9. Liu D, Ishima I, Tong KI, et al. Solution structure of a TBP-TAFII230 complex : Protein mimicry of the minor groove surface of the TATA box unwound by TBP. Cell 1998 ; 94 : 573-83.
- 10. Kamada K, Shu F, Chen H, et al. Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. Cell 2001 ; 106 : 71-81.
- 11. Dantonel JC, Wurtz JM, Poch O, et al. The TBP-like factor : An alternative transcription factor in metazoa? Trends Biochem Sci 1999 ; 24 : 335-9.
- 12. Crowley TE, Hoey T, Liu JK, et al. A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Nature 1993 ; 361 : 557-61.
- 13. Rabenstein MD, Zhou S, Lis JT, Tjian R. TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. Proc Natl Acad Sci USA 1999 ; 96 : 4791-6.
- 14. Teichmann M, Wang Z, Martinez E, et al. Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells. Proc Natl Acad Sci USA 1999 ; 96 : 13720-5.
- 15. Moore PA, Ozer J, Salunek M, et al. A human TATA binding protein-related protein with altered DNA binding specificity inhibits transcription from multiple promoters and activators. Mol Cell Biol 1999 ; 19 : 7610-20.
- 16. Hansen SK, Takada S, Jacobson RH, et al. Transcription properties of a cell type-specific TATA-binding protein, TRF. Cell 1997 ; 91 : 71-83.
- 17. Persengiev SP, Zhu X, Dixit BL, et al. TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Proc Natl Acad Sci USA 2003 ; 100 : 14887-91.
- 18. Holmes MC, Tjian R. Promoter-selective properties of the TBP-related factor TRF1. Science 2000 ; 288 : 867-70.
- 19. Takada S, Lis JT, Zhou S, Tjian R. A TRF1/BRF complex directs Drosophila RNA polymerase III transcription. Cell 2000 ; 101 : 459-69.
- 20. Dantonel JC, Quintin S, Lakatos L, et al. TBP-like factor is required for embryonic RNA polymerase II transcription in C. elegans. Mol Cell 2000 ; 6 : 715-22.
- 21. Kaltenbach L, Horner MA, Rothman JH, Mango SE. The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis. Mol Cell 2000 ; 6 ; 705-13.
- 22. Veenstra GJ, Weeks DL, Wolffe AP. Distinct roles for TBP and TBP-like factor in early embryonic gene transcription in xenopus. Science 2000 ; 290 : 2312-5.
- 23. Muller F, Lakatos L, Dantonel J, et al. TBP is not universally required for zygotic RNA polymerase II transcription in zebrafish. Curr Biol 2001 ; 11 : 282-7.
- 24. Hocheimer A, Zhou S, Zheng S, et al. TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila. Nature 2002 ; 420 : 439-45.
- 25. Shimada M, Nakadai T, Tamura TA. TATA-binding protein-like protein (TLP/TRF2/TLF) negatively regulates cell cycle progression and is required for the stress-mediated G(2) checkpoint. Mol Cell Biol 2003 ; 23 : 4107-20.
- 26. Martianov I, Fimia GM, Dierich A, et al. Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene. Mol Cell 2001 ; 7 : 509-15.
- 27. Martianov I. Brancorsini S, Gansmuller A, et al. Distinct functions of TBP and TLF/TRF2 during spermatogenesis : Requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Development 2002 ; 129 : 945-55.
- 28. Lescure A, Lutz Y, Eberhardt D, et al. The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters. EMBO J 1994 ; 13 : 1166-75.
- 29. Lee M, Struhl K. Multiple functions of the nonconserved N-terminal domain of yeast TATA- binding protein. Genetics 2001 ; 158 : 87-93.
- 30. Mittal V, Hernandez N. Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science 1997 ; 275 : 1136-40.
- 31. Khrapunov S, Pastor N, Brenowitz M. Solution structural studies of the Saccharomyces cerevisiae TATA binding protein (TBP). Biochemistry 2002 ; 41 : 9559-71.
- 32. Hobbs NK, Bondareva AA, Barnett S, et al. Removing the vertebrate-specific TBP N terminus disrupts placental β2m-dependent interactions with the maternal immune system. Cell 2002 ; 110 : 43-54.
- 33. Schmidt EE, Bondareva AA, Radke JR, Capecchi MR. Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein. J Biol Chem 2003 ; 278 : 6168-74.
- 34. Um M, Yamauchi J, Kato S, Manley JL. Heterozygous disruption of the TATA-binding protein gene in DT40 cells causes reduced cdc25B phosphatase expression and delayed mitosis. Mol Cell Biol 2001 ; 21 : 2435-48.
- 35. Johnson SA, Dubeau L, Kawalek M, et al. Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis. Mol Cell Biol 2003 ; 23 : 3043-51.
- 36. Martianov I, Viville S, Davidson I. RNA polymerase II transcription in murine cells lacking the TATA binding protein. Science 2002 ; 298 : 1036-9.
- 37. Christova R, Oelgeschlager T. Association of human TFIID-promoter complexes with silenced mitotic chromatin in vivo. Nat Cell Biol 2002 ; 4 : 79-82.
- 38. Wieczorek E, Brand M, Jacq X, Tora L. Function of TAFII-containing complex without TBP in transcription by RNA polymerase II. Nature 1998 ; 393 : 187-91.