Abstracts
Résumé
La leucémie lymphoblastique aiguë (LLA) est le type de cancer le plus fréquemment diagnostiqué chez l’enfant. Les traitements de radiation crânienne et de chimiothérapie administrés permettent un excellent taux de survie. Cependant, ces traitements causent divers effets à long terme affectant la qualité de vie des survivants. Cette revue de littérature aborde les effets à long terme des traitements contre la LLA sur le fonctionnement cognitif et les structures cérébrales. Les atteintes de la substance blanche et grise ainsi que les déficits cognitifs fréquents, leur relation avec les agents de traitement et les mécanismes expliquant leur apparition graduelle y sont décrits.
Mots-clés :
- leucémie lymphoblastique aiguë,
- traitements,
- difficultés neurocognitives,
- atteintes cérébrales,
- apparition à long terme
Abstract
Acute lymphoblastic leukemia (ALL) is the most frequently diagnosed cancer in children. Because of the administration of cranial radiation and chemotherapy, survival rate is excellent. However, ALL treatments can cause different long-term side effects, which can affect quality of life in survivors. This review of the literature describes the long-term effects of ALL treatments on cognitive functioning and cerebral structures. White and grey matter damages, frequent cognitive deficits, their relation with treatment agents as well as mechanisms explaining their gradual apparition are discussed.
Keywords:
- acute lymphoblastic leukemia,
- treatments,
- neurocognitive difficulties,
- cerebral damages,
- long-term apparition
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Appendices
Remerciements
Les auteurs tiennent à remercier l’IRSC, la Société de recherche sur le cancer, la Société canadienne du cancer, le C17 Council, le Pediatric Oncology Group of Ontario (POGO) et la Garron Family Cancer Centre du Hospital for Sick Children pour avoir subventionné cette recherche et permis sa réalisation.
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