McGill University Theses and dissertations published in 1964

The folic acid group: The discovery of Methotrexate and some of the other antimetabolic agents that are currently being used for the treatment of neoplastic disease is a long and colorful epic, beginning about thirty years ago. The development of these “folic acid analogs” was intimately tied in with the elucidation of one of the B complex vitamins, folic acid. Folic acid (pteroylglutamic acid) is found in many natural materials.  Read more

Before studying the question of relations between the Indian Muslims and the British in India in the early 19th century, it would be helpful if we knew what the Muslims of that period were thinking about the political situation of the country. Here we will not go into detail about the political situation, because any book of political history can serve this purpose. Since we have to see the relations between these two groups during the time of Shâh 'Abdul 'Aziz, we will limit ourselves to him and his opinion about the political situation. Till the end of the 18th …  Read more

The theory of one-dimensional singular integral equations with Cauchy type kernels has been used to great advantage in recent years, in solving many problems encountered in the various branches of Mathematical Physics such as elasticity and fluid mechanics. The fundamentals of the theory appeared independently in papers by H. Poincare and D. Hilbert shortly after the development of the theory of Fredholm equations: Hilbert was working on boundary problems in the theory of analytic functions, while Poincaré was studying the general theory of tides. Although the problems mentioned above often reduced to singular equations of this type, the theory remained …  Read more

This thesis deals with the computation and study of small elastic displacements and stresses in axially symmetric spherical shells. All loads and reactions are assumed to be symmetrical with respect to the axis of the shell and consequently the displacements and stresses are functions of only one independent variable, the co-latitude. Although the application of major interest to the author is the analysis of reinforced concrete shell roofs, the theory is equally applicable to the design of tanks and pressure vessels, radomes, nuclear reactor containment vessels and other structural components in the form of a spherical cap.  Read more

The purpose of this study was to compare the change in marks from the grade seven June examination to the grade eight Easter examination of one group taught effective learning skills through the medium of a regular grade eight history course, with a second group which experienced nondirective group counseling, and with a control group. The change in marks of a control group which received no special treatment was used as the base line of normal school progress in the two criterion subjects of history and English.  Read more

The purpose of this thesis is to describe in detail the fonn, lithology, elevation, tflt and distribution of abandoned glacial lake shoreline features and associated fluvioglacial and glacial deposits of Southwest Labrador Qnap 1). These characteristics are the result of distinct geomorphic and geophysical processes operating in late glacial and post glacial times and therefore a study of these characteristics reveals certain facts about the glacierization of Labrador-Ungava* and the deglaci erization of Southwest Labrador. The tilt of the glacial lake shoreline features is a result of glacial isostatic recovery and therefore the tilt of the shorelines reflects the differentiai …  Read more

Among the physiological features of the infected plant, the pathological increase in respiration is a striking one. This altered rate of respiration, usually measured in terms of oxygen uptake, starts before symptoms of disease appear, rises gradually to a maximum as the disease develops, and declines rapidly as death is approached. These observations on abnormal rate of gas exchange indicate that the enzyme-catalysed processes resulting in oxygen absorption are accelerated in the host tissue as a result of infection. A natural question is then, what enzymes are involved in this acceleration. Among the great variety of enzymes that could possibly …  Read more

Ribonucleic acid (RNA) of tobacco mosaic virus controls the specificity of viral proteins synthesized in the cells of tobacco leaves (Fraenkel-Conrat et al, 1957a) and in a bacterial cell-free system (Taugita et al, 1962). In bacteria, three types of RNA are now recognized, transfer (Berg and Ofengand, 1958), ribosomal (Schachman et al, 1952), and a so-called "messenger” or “rapidly labelled" RNA (Volkin and Astrachan, 1956). The “messenger” fraction is thought to control the specificity of proteins synthesized in bacterial cells (Nomura et al, 1960; Brenner et al, 1961; Gros et al, 1961a; Jacob and Monod, 1961), although direct proof for …  Read more

The Sault Ste. Marie map-area lies at the western end of the Huronian belt along the north shore of Lake Huron. It includes rock formations that range in age from highly metamorphosed early Precambrian basement rocks to unmetamorphosed, flat-lying Cambrian sediments and unconsolidated Pleistocene glacial materials. The rock formations of the Sault Ste. Marie area have been arranged by earlier workers (McConnell 1926) into five major structural and stratigraphic elements, each quite distinct in age and character.  Read more

Positrons can be used as a probe in the investigation of metals. We intend here to investigate one aspect of their use. We will develop a theoretical description of the interaction of one positron with a sea of electrons. Then with the use of this model we will investigate the possible existence of a quasi-bound state of the positron. Most investigations into annihilation of positrons ignore the possibility of the formation of a quasi-bound state and it's effect on positron lifetime. It is assumed that; a positron introduced into the 'electron gas' will be annihilated from a scattering state.  Read more

The metabolism of the mature mammalian erythrocyte can be considered anomalous in relation to most types of somatic cells, including those from which the erythrocyte is derived. Erythropoiesis takes place mainly in the bone marrow, and is presumed to occur in the following stages: stem blast cell- erythroblast - normoblast - reticulocyte - erythrocyte. The cells up to and including the normoblast stage have a well defined nucleus, whereas the reticulocyte contains only stainable granules believed to be ribonucleoprotein. The mammalian erythrocyte lacks bath the nucleus and stainable granules.  Read more

The utilization of radar as a method of observing clouds and cloud patterns has been most beneficial in the quest for an understanding of cloud physical processes, because radar is capable of "seeing" into the central parts of precipitating clouds, and can reveal the distribution and development of the precipitation patterns within them. One of the first extensive programs that used radar as a cloud physical research tool was the Thunderstorm Project (1949), which was carried out in Florida and Ohio in 1946 and 1947. Radar was used in this project to locate the levels of formation of first radar …  Read more

This study is based on twenty weeks field work in the Caribbean during the months of May, June, July, August and September, 1963. Three weeks of this time were spent working in the libraries of the University of the West Indies at Mona, Jamaica and St. Augustine, Trinidad and of the University of Puerto Rico at San Juan, Puerto Rico. Brief visits were made to other islands, for example Tobago, St. Lucia, Martinique, Antigua and St. Maarten, for comparative purposes. The research project was undertaken as part of the McGill University Geography Department Tropical Programme. In Barbados the Programme has …  Read more

The infestation of Pinus species in Ontario by species of Conophthorus Hopkins has been recognized for some time. Damage to the cones and shoots of eastern white pine, Pinus strobus Lamb., by Conophthorus coniperda (Schwarz) was noticed about 1884 (Harrington 1902a). Similar damage to red pine, P. resinosa Ait., due to C. resinosae Hopkins was reported by Harrington (1902a) to have been discovered several years later in 1887. Thomas and Lindquist (1956) and Herdy and Thomas (1961) have reported that shoots of jack pine, P. banksiana Lamb., are infested by Conophthorus species. The mining of Scots pine shoots, P. sylvestris …  Read more

In a report presented by Frens (1955) it was pointed out that, apart from some exceptional cases, an extension of the present grassland area could not be advocated in a great number of countries. Consequently, efforts will have to be concentrated on intensifying the production of the existing grassland area or improving the quality of grass. It was stressed that at the same time the best possible management practices would be required. On the basis of the 1951 census, Raymond (1958) in a bulletin on pastures for Quebec showed improved pastures in the province as having a carrying capacity of …  Read more

The toxigenic theory of plant disease explains the occurrence of pathological disturbances in advance of the invading pathogen as the effect of a toxin produced in the course of host-pathogen interaction. A considerable amount of work has been done on such diseases, which are called toxemia; however much of it is still a matter of controversy. Much more research must be done on this subject before many of the concepts involved can be accepted. At present, there is need for studies to show that pathogens can produce the same toxins both in axenic culture and in infection, and that injection …  Read more

"In the nineteenth century the white has made a man out of the black, and in the twentieth, Europe will make a world out of Africa." These words, written by W. G. Blaikie, author of "Life of Livingstone," express the fairly general attitude of the last twenty years of the nineteenth century in Britain. Africa, a few years earlier, had been comparatively unknown, except along the coast lines. Livingstone, with his adventurous and noble feats, had changed this greatly, and had made Africa a focal point of interest, not only for the casually curious, but also for the statesman, merchant, …  Read more

In his review of 1946 Pitts (110) presented a concept of the central nervous control of breathing which accounted for many of the experimental observations made up to that time, and in particular for the phenomenon of maintained inspiration or apneusis seen in vagotomized animals sectioned at the midpontile level (69, 100, 112, 133, 137). According to the hypothesis propounded by Pitts there are anatomically separate inspiratory and expiratory centres in the medulla, located in close spatial relationship one to the other. These centres could be differentially activated by localized electrical stimulation of points in the medulla (112).  Read more

The Peace and Pine River Foothills lie east of the Rocky Mountains between Latitude 55° 30' and 56° 15' North. The rocks exposed in the Foothills are of Permian, Triassic, Jurassic and Cretaceous ages. [...]  Read more

In earlier reported studies from this laboratory (Share and Melville, 1961; Varma et al, 1962; and Melville and Share, 1963) it was shown that injection of the convulsant drug, picrotoxin, into the lateral cerebral ventricles of cats and rabbits can lead to a rise in arterial blood pressure associated with various types of electrocardiographic ST-T alterations and cardiac arrhythmias (bradycardia, tachycardia, extrasystoles and even ventricular fibrillation in rabbits). It was suggested that these cardiovascular effects of picrotoxin were mediated through central excitation of adrenergic mechanisms, probably involving "release" of catecholamines (noradrenaline mainly) from the hypothalamus and midbrain.  Read more

A recombination bolometer for the detection of atomic hydrogen was designed and constructed. The bolometer consisted of a platinum disk, to the back of which was bonded a small bead type thermistor. The recombination of atoms upon the surface of the disk provided sufficient heat that a substantial change in the resistance of the thermistor was observed. As part of a testing program for the device, the relative sensitivity defined as (change in temperature/relative number of atoms present) was measured for atomic hydrogen, nitrogen and oxygen. Since the three atoms studied are paramagnetic, it was possible to determine their relative …  Read more

Je médite depuis longtemps le rôle de la femme dans le théâtre de Claudel. Or aucun écrivain français si ce n'est Racine n'a créé de femme qui puisse être comparée à la femme claudélienne sans souffrir de la comparaison. Les grands rôles féminins dans le théâtre de Claudel – ceux de Prouhèze, d'Ysé et de Violaine -- sont uniques dans leur profondeur et leur puissance et une étude sérieuse des rôles mineurs découvre une richesse peu soupçonnée au premier abord. D'ou vient cette richesse? Elle vient de la conception que Claudel a eue de la Femme. Elle vient du rôle …  Read more

The gaps in a nuclear reactor, provided for experimental research or the flow of a coolant gas, permit the neutrons to flow from one region of the reactor to another. This effect, referred to as streaming, is usually accounted for in reactor design calculations by Behrens’ theory an application of the chord method originally developed by Cauchy. A Monte-Carlo program has been developed in this study to test the validity of Behrens’ theory, and to extend its applications by considering effects not included in that theory. Various void shapes and sizes relative to the moderator have been studied. Results have …  Read more

Discussions with regard to circulatory alterations in shock and the end results of these changes have gone on for many years. As early- as 1944 vasoexcitor and vasodepressor substances in shock states were postulated and efforts were made to identify the substances responsible. These studies represented one of the first steps in the search to find a single substance as a common denominator in various forms of shock. Recent studies of polypeptides, their biological activity and affect on vasomotor tone have suggested their possible importance in shock states. The more recent studies by Moffat on Bradykinin release in pancreatitis, and …  Read more

A theory of operation, design recommendations and performance limits of torque meters, based on magnetic-stress anisotropy, have been established. The theory, based on considerations of total magnetic-crystal energy, successfully explains both the qualitative and quantitative behaviour of these devices. The theory has been checked and the design recommendations have been established by measurement of the behaviour of steel and nickel torque tubes of various wall thicknesses over a range of magnetizing force, frequency and stress. It has been established that sustained accuracies of better than 1% are readily obtained, the limit of accuracy being of the order of 0.1%. Such …  Read more

Strain rates ranging from 20% to 100% per second were used in consolidated-undrained triaxial tests, to investigate the influence of rate effects on the behaviour of cohesive soils. To apply the required loading rates, a hydraulic test unit was designed. Techniques were developed for producing saturated remoulded samples and for measuring the applied stresses, strain and pore pressures in the dynamic test. Electrical instrumentation was used for sensing and recording the transients. No pore pressure measurements were obtained in the dynamic tests conducted. For the same consolidation pressure, the strength of samples as determined in a triaxial test increased with …  Read more

Labrador's coastal scenery is dominated by evidence of Pleistocene glaciation. Before World War II only a few, generally bread studies touching on this subject bad been made in Labrador. From these the overwhelming effect of continental glaciation became clear. However, the chronology of glaciation had yet to be established, and little regional evidence bad been obtained to support existing hypotheses explaining the character and effects of Labrador-Quebec's glaciation. Expeditions like that of Vainö Tanner (1944) have shown that studies in detail or concentrated in small areas are essential if the deglaciation and emergence of coastal Labrador are to be understood.  Read more

Research between the two world wars on the causes of juvenile delinquency was dominated by scholars from Chicago. It was a period of exploration on a grand scale in which sociologists were aligned with each other in their search to uncover sociological factors in crime causation and in their desire to maintain an approach which was distinct from other approaches to the problem – namely that of psychologists. It was a period in which great contributions were made to theory and methodology. And it provided the foundations for the post war theories with which this research project is primarily concerned.  Read more

The etiology of endemic pneumonia in rats has been investigated, and the specific cause of the condition was established. A viral agent was isolated in rat embryo skin primary tissue cultures, and postulates have been fulfilled for identifying this viral agent with endemic pneumonia in rats. Some characteristics of this virus were established. A method for demonstrating the cytopathogenic agent, involving two-step incubation of inoculated tissue cultures at two different temperatures has been described. This technique was successfully employed for the isolation of the virus responsible for endemic pneumonia in rats.  Read more

Ragweed hay fever makes thousands of people miserable every year. These people have an allergy to ragweed pollen. The characteristic symptoms include rhinitis, sneezing, nasal blockage and itching of the nose, eyes and throat. These symptoms appear in sensitive people soon after ragweed pollen is introduced into the environment. They occur every year from about the middle of August until the first frost, during the time that the wind-pollinated plant is dispersing its heavy load of pollen. The plants causing most trouble are the short ragweed, Ambrosia artemisiifolia L. var. elatior (L.) Descourtils, giant ragweed, Ambrosia trifida L., and western …  Read more

Kaada (1951) reported that electrical stimulation immediately anterior to and directly below the genu of the corpus collosum (septal area) produced inhibition of various autonomic and somatamotor responses. On the other band, he found that stimulation above the corpus collosum in the area of the anterior and midcingulate cortex yielded facilitation of these same reactions. Based on Kaada's data, McCleary (1961) found a difference between these two loci at the behavioral level. Cats sustaining bilateral subcallosal lesions were deficient in acquiring a passive avoidance response (PAR).  Read more

The mechanism of the formation of the molluscan shell has been the subject of controversy since the first observations were made by Reaumer in 1709 on the normal growth and regeneration of shells. There is considerable agreement on the sites of secretion of the shell materiel and the histological identity of these tissues. However, controversy centres about the mechanism by which the organic matrix of the inner layers of the shell is released into the extra-pallial space, by which it is deposited and subsequently calcified. The controversy has, of late, gained importance in that it provides excellent possibilities for the …  Read more

Boys’ Clubs are presently undergoing a painful period of re-orientation. They are beginning to look beyond their boy-centered recreational programs into the community and the manifold problems and challenges it presents. They are, in the language of the Boys' Clubs, becoming extremely "guidance conscious." The purpose of this study is to examine the guidance component of a guidance conscious Boys' Club.  Read more

Palmer, W. (Supervisor)  Read more

The subject matter of this study is the analysis of “Labour Problems in the Industrialization of Pakistan". Industrial development has become a major consideration of policy for underdeveloped countries. Pakistan, like at her emerging nations, has commit ted herself to the rapid industrialization of her primarily agricultural economy. She aspires, through it, to attain higher living standards, to eliminate mass illiteracy, and to eradicate diseases. “Industrialization refers to the actual course of transition from the traditional society towards industrialism". (1) For such a process of development a country needs capital, technology, natural resources, entrepreneurs and skilled and professional manpower.  Read more

The analysis of glacier wasting is a tripartate study which includes: the measurement of the quantity of wasting, an examination of the causes of wasting, and an investigation of the means of disposal of the waste products. This particular investigation is an attempt to improve upon the accuracy of measurements of wasting so that future investigators will be able to make more meaningful statements regarding cause. In the 1930's the first quantitative studies of the heat exchange at a melting ice surface were made in Scandinavia. By measuring the heat received at the surface from radiation, convection and conduction from …  Read more

Levitt, K. (Supervisor)  Read more

The present hospital mortality rate for myocardial infarction is reported as 47%, and when shock occurs it is said to be above 85% regardless of the type of therapy. Most of these patients die in left heart failure. It is obvious that present treatment of myocardial infarction is inadequate and a new approach is required. The answer appears to lie in some type of support to the heart which could adequately maintain systemic and coronary circulation, while the damaged myocardium recovers from its injury. With such assisted circulation surgical correction could be accomplished in isolated lesions and collateral circulation might …  Read more

The possibility of extending the range of operation of turbojet engine to hypersonic Mach number and its possible uses have been investigated. It is well known that addition or an afterburner extends the range of turbojet to Mach number of about 3. A further addition or a cooling system between ram intake and compressor can extend this range to Mach number of up to 6, depending upon the specific impulse required. A study of the choice of cooling systems for the precooled turbojet has been made. Liquid methane is used as the fuel and while passing through a heat exchanger …  Read more

The patterns of land subdivision form an essential element in the analysis of an urban area. In this essay an attempt is made to evaluate the importance of these patterns for urban growth on the Island of Montréal. The approach is an historical one, since the understanding of past patterns aids in our comprehension of the present. Thus in Part One the historical background to land granting procedures is examined, firstly in the Province of Québec, and then for the Island of Montréal. The cadastral divisions of the Island are discussed in Chapter Three, and a classification of the long …  Read more

Naylor, A. F.  Read more

Lloyd, T. (Supervisor)  Read more

In this treatise the convergence of iterative algorithms for the solution of non-linear operator equations in complex linear topological spaces are studied from the point of view of fixed-point theorems in such spaces... It was felt that the concept of the Gâteaux differential is a more natural one to use in connection with linear topological spaces. The beauty of the developed technique we mentioned earlier is essentially due to the fact that we are considering spaces over the complex number field. The resulting convergence theorems have also the added advantage of imposing no conditions on the second or higher order …  Read more

Leblond, C. (Supervisor)  Read more

Donefer, E. (Supervisor)  Read more

The application of the thermal wind equation to daily analysed data provides the basis for computed ageostrophic wind fields. The numerical integration used in computing the geostrophic wind avoided any subjectivity but led frequently to an upward amplification of the error field. The study shows the tropopause and the jet streams as generators of strong ageostrophic wind. The same equation applied to mean data shows a general long period geostrophic balance, but there are signiticant seasonal differences and the tropopause remains a permanent zone of ageostrophic wind. [...]  Read more

Patil, G. P.  Read more

Hillman, Donald.  Read more

Lowther and Boll in the study of the effect of 2,4,5-TCPAA on etiolated bean leaf discs observed that inhibition of expansion at low concentrations was relieved at high concentrations where growth was equal to that of the light plus Co control. This means that at appropriate concentrations, TCPAA completely replaced Co in the expansion of light-treated leaf discs. [...]  Read more

Henneberry, G. O.  Read more