Résumés
Résumé
Les protéines signalisatrices des familles Wingless/Wnt, Hedgehog et Decapentaplegic (Dpp)/Bone morphogenic protein (BMP) agissent comme des morphogènes au cours du développement. On sait aujourd’hui que ces molécules sécrétées agissent directement sur des cellules pourtant distantes de leurs sites de production, mais peu de choses sont connues sur la façon dont ces molécules se propagent au sein d’un tissu, et sur les mécanismes contrôlant cette propagation. Des travaux récents réalisés chez la drosophile, mêlant des approches génétiques à des approches de biologie cellulaire, ont permis de révéler que le processus d’endocytose joue un rôle central dans le contrôle de la propagation d’un morphogène.
Summary
During development, secreted signaling proteins of the Wingless/Wnt, Hedgehog and Decapentaplegic (Dpp)/ Bone Morphogenic Protein (BMP) families act as morphogens. Previous work had shown that these molecules act directly on distant cells, although until recently nothing was known about how they reach those distant cells. During the past two years, work carried out on Drosophila using genetic and cell biology approaches have revealed that endocytosis plays a central part in the mechanisms that control the spread of morphogens.
Parties annexes
Références
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