McGill University Thèses et mémoires publiés en 1988

Imai, Hiroshi (Supervisor)  Lire la suite

The structure of the carbohydrate associated with glycoproteins was examined in various human colonic tumour cells in culture following incubation with labeled sugars. Glycopeptides obtained by pronase digestion of the cell surface glycoproteins of three human colon tumours (HCT-8R, CaCo-2, and HCT-15) were compared with those from cells (CCL 239) derived normal adult colon. The tumour cells contain large molecular weight fucose-labeled glycopeptides that are absent in the CCL 239 cells. The large molecular weight fucose- and glucosamine-labeled glycopeptides from HCT-8R cells contain mainly mild alkali labile O-linked oligosaccharides, whereas those isolated from CaCo-2 cells contain primarily N-linked polylactosaminoglycans which …  Lire la suite

This qualitative naturalistic research study investigated peer interaction and its relationship to the learning of Logo geometry concepts within an elementary school computer lab classroom environment. The work of four focal children (10-11 years old) and their partners was analyzed. The study looked at (1) the kind of working relationships which existed between the partners, (2) the verbal strategies used by the partners during their mathematics disagreement, and (3) the ways in which the talk between the partners and the strategies they used both contributed to their learning, and reflected their learning, of the geometry concepts (with an emphasis upon …  Lire la suite

A crucial requirement for the stepwise, continued growth of a brain tumor is the acquisition of a blood supply from the host, i.e. angiogenesis. The mechanisms of copper activity linked to neovascular and neoplastic growth are largely unknown. Copper ion was shown to be a cofactor for angiogenesis. We tested the effect of copper depletion achieved by a low copper diet and a copper chelator D-penicillamine, on the intracerebral growth of two experimental brain tumors. We developed in in vivo brain tumor model using the VX2 carcinoma. Implantation of 5 $ times$ 10$ sp5$ VX2 carcinoma cells into the parietal …  Lire la suite

This thesis proposes a quantitative model of fatigue crack initiation and early propagation based on a plastic strain intensity factor $ Delta{K} sb{p}$. In this model, the crack growth rate in the initiation region is simplified as a straight line on the log-log scale of da/dN verses $ Delta{K} sb{p}$ curve. A turning point which divides crack growth into the initiation and propagation regions is introduced as the plastic crack propagation threshold, $ Delta{K} sb{pth}$, whose value is determined by the plastic crack propagation threshold in the $ Delta{J}$-integral form, $ sqrt{ Delta{J} cdot{E}} sb{pth}$. The crack propagation style in …  Lire la suite

The binding of selected bile acids and bile pigments by peptides and quaternary amines has been studied by adsorption and NMR experiments. Novel adsorbents with quaternized peptide-containing functional groups for bile acids have been prepared by solid phase peptide synthesis techniques. The adsorption studies, conducted in aqueous buffer solutions, show that these resins have an enhanced capacity, on a per active site basis, and improved specificity over cholestyramine and colestipol. The interaction between bile acid anions and the pendants is predominantly ionic linkage, although hydrophobic and other interactions are also important. An NMR study of the binding between bile acids …  Lire la suite

This thesis is devoted to the optimal commitment of generation units in an all-thermal, single or multiple area, power system. The problem, known as unit commitment, is a nonlinear mixed program typically with thousands of 0-1 integer variables and diverse constraints. An exact optimal solution to the problem is only possible via (explicit or implicit) enumeration, which requires a prohibitively long computation time for large problem instances. Two optimization approaches, Lagrangian relaxation and simulated annealing, are explored in this thesis for efficient and near-optimal unit commitment. Lagrangian relaxation combines the solution of the dual of the unit commitment problem with …  Lire la suite

The purpose of the present study is to analyze the structural techniques and genre of Chekhov's plays. The many books and articles published on Chekhov's plays far exceeds his own works. Although there have been numerous studies analyzing the structural techniques of his play, considerable controversy still exists among literary and theatre scholars regarding the genre of his plays. Most of the studies simply avoid this complex and intricate problem. In this study particular emphasis is also placed on the dramatic techniques used by Chekhov: the sequence of events, the nature of the roles and the so-called "unfinished" endings.  Lire la suite