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2024 — Exploration of the antimicrobial capabilities of Pantoea: Insights into a metabolically diverse genusRésumé
The rise of antimicrobial resistance has once again renewed interest in the development of novel antimicrobials for the treatment of resistant pathogens. The genus of bacteria Pantoea, a member of the Erwiniaceae, has been shown to produce several unique antimicrobials with diverse targets. Chapter one gives a review of the known antimicrobials produced by Pantoea including their discovery, genetic origins, biosynthetic pathways, structures, mechanisms of action and resistance, distributions, and insights into their evolutionary histories. Chapter two describes a replica-plating technique that was developed to quickly and easily screen transposon mutant libraries to discover the biosynthetic gene clusters responsible for … Lire la suite
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2012 — Identification, distribution and evolution of three type III secretion systems and their effectors in the pathogen, Pantoea stewartii sp. stewartii DC283Résumé
The type III secretion system (T3SS) is an extracellular appendage used primarily by bacteria for pathogenesis in both plants and animals, including humans. Related to the bacterial flagellum, this nanomachine uses an extracellular pilus to actively transport effector proteins from Gram-negative bacteria directly into the host cell to cause disease. One genus that uses the T3SS is Pantoea, which comprises several well-studied plant pathogenic species, as well as opportunistic human pathogenic species. Three T3SSs were identified in a diverse collection of Pantoea representing plant, clinical and environmental samples: a plant-specific T3SS Hrc 1, and two animal-specific T3SSs, SPI-1 and SPI-2. … Lire la suite
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2017 — Role of the Neurotransmitter Glutamate in Neural Stem and Progenitor Cells Differentiation into OligodendrocytesRésumé
Various regions of the mammalian brain, including the subventricular zones (SVZs) of the hippocampus and the dentate gyrus (DG), contain niches of undifferentiated neural stem and progenitor cells (NSPCs) which persist from development, all throughout adulthood. These cells can differentiate into the three main cell types found within the brain: neurons, oligodendrocytes (OLs), and astrocytes. Adult NSPCs can be driven to specific cells of interest which can be used to replace lost myelin in some cases of neurodegenerative diseases such as multiple sclerosis (MS) or insults such as spinal cord injury. I investigated the requirements to drive immature NSPCs into … Lire la suite
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2022 — Deformation bands and their relationship to syn-to post-Athabasca faulting and unconformity-related uranium deposits: A case study and comparison of the C1 fault corridor and WS shear zone (Gryphon and Phoenix deposits) in the eastern Athabasca BasinRésumé
Saskatchewan is home to world-class uranium (U) deposits associated with the unconformity between the Proterozoic Athabasca Basin and underlying Archean- Paleoproterozoic basement rocks. Many deposits exhibit a strong spatial association with post-Athabasca faults formed by the reactivation of basement-rooted structures. Deformation bands are products of localized strain in porous sedimentary rocks and are commonly associated with fault damage zones. They can significantly modify porosity due to grain rotation and granular flow. This study investigated deformation bands in sandstones of the basal Manitou Falls Group in eight drillhole fences that transect two fault corridors in the eastern Athabasca Basin: the NNE-trending … Lire la suite
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2012 — Recovered Accounts of Saskatchewan Adult Education: A Governance MomentRésumé
While a good deal is known about the history and governance structures within the Saskatchewan K-12 system, very little is known about the adult education and training sector. Faris (Cassidy & Faris, 1987) indicates that, given the magnitude and importance of the sector, the low status and remarkably little attention paid to the field of adult education is puzzling. Accordingly, the purpose of this study is to understand and synthesize the lived-experiences of key decision-makers in order to make recommendations to improve the governance of the Saskatchewan adult education and training sector. Moreover, it is disturbing to find that the … Lire la suite
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2018 — A Case Study of the Lived Experiences of Individuals: How Experiential Exercises Aid Entrepreneurship Teachers to Understand Intrapreneurship and the Art of Entrepreneurial ThinkingRésumé
This research addressed a gap in our knowledge and understanding of if, how, and why experiential exercises might aid teachers to introduce to Entrepreneurship 30 an expanded understanding of the phenomena of entrepreneurship and the “art” of entrepreneurial thinking. A group of five Entrepreneurship 30 teachers attended a 2-day workshop where they were introduced by modelling to a series of experiential exercises. This was followed by a 6-week observation period with interviews. The case study represents the discovery, insight, and understanding of the lived experiences of the research participants as they rejected, adopted, or adapted the material into the curriculum. … Lire la suite
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2024 — Making (in)visible: Marginality, neurodiversity and COVID-19 in urban SaskatchewanRésumé
People with disabilities have been coined invisible citizens during the COVID-19 pandemic. This research responds to the ways people with disabilities and other intersecting marginalities were made invisible during COVID-19 in urban Saskatchewan. Using arts-based participatory this research asks, “what are the practices that worked to invisibilize people with disabilities and intersecting marginalities during the COVID-19 pandemic?” To explore this question the project worked with three community-based organizations and individuals with disabilities in Regina Saskatchewan to unpack stories and truths while co-designing a creative outcome focused on lived experiences of COVID-19. Analysis explores the broader contexts in which people with … Lire la suite
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2014 — Low-Cost Grain Bin Moisture Sensor Using Multiple Capacitive ElementsRésumé
The ability to know the condition of grain stored on the farm is very important. Grains grown in the prairie provinces of Canada are valuable commodities and the farm has become a primary storage location for more and more grain as farming operations have been getting larger and larger. With increased storage, the risk of spoilage is ever present. Both spoilage and the cost of drying grain reduce profit. These factors have created a need for better on farm management of stored grain, and therefore a need for a reasonable cost sensor to continuously monitor the moisture inside the bins. … Lire la suite
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2012 — The measurement of stride-to-stride fluctuations in the gait of young and older adults using a body-fixed, tri-axial accelerometer.Résumé
Falls represent one of the most significant health problems that affect older adults. Having the ability to accurately analyze and screen the gait of individuals who may be at risk of falling is an essential step to improving their health. Research has shown that there are numerous age-related changes in gait and that these changes may increase the risk of falling. More important than mean spatiotemporal parameters of gait, are the stride-to-stride fluctuations inherent in these measures. Both gait variability (i.e., the standard deviation of spatiotemporal gait parameters) and fractal dynamics (i.e., the patterning of fluctuations observed over a larger … Lire la suite
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2020 — An Intelligent System for Type II Diabetes Mellitus DiagnosticRésumé
Diabetes mellitus is a modern world burden mentally, physically, and economically. Diabetes mellitus occurs when the blood sugar level reaches too high levels. Some of the significant complications of diabetes mellitus are cardiovascular diseases, major organ damages, Alzheimer's, depression, and in further stage losing a life. The diagnosis of diabetes mellitus is a complicated and time-consuming problem. In the diagnosis process, a medical expert has to investigate many factors, such as age, gender, body mass index and blood glucose level. Also, after the first laboratory tests and medical exam results, if the first laboratory test is affirmative for disease, the … Lire la suite
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2021 — Statistical Summary Representations in Identity Learning: Exemplar-Independent Incidental RecognitionRésumé
The literature suggests that ensemble coding (i.e., the ability to represent the gist of sets) may be an underlying mechanism for becoming familiar with newly encountered faces. I tested the plausibility of this suggestion using a new paradigm that involves incidental learning of target identities interspersed among distractors. The participants were trained on unfamiliar targets that were presented among intervening distractors while rating the attractiveness of the faces. The participants were then given a test to measure their familiarity with the targets. The results revealed that recognition of a target’s face was superior when the face was the average of … Lire la suite
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2024 — Development of scintillator-based components for the photosensor system for the Intermediate Water Cherenkov Detector of the Hyper-K experiment and for the time of flight system of the Water Cherenkov Test ExperimentRésumé
The existence of the neutrino flavour oscillation phenomenon carries a potential CP-violation phase, 𝛿CP, that might be the answer to the matter-antimatter asymmetry question in the Universe. With a new far detector and upgraded components of the successful Tokai-to- Kamioka (T2K) experiment, the long-baseline aspect of the Hyper-Kamiokande (Hyper-K) experiment will utilize an upgraded neutrino beam from the Japan Proton Accelerator Research Complex (J-PARC). The measurement of 𝛿CP from 𝜈𝜇 and ¯ 𝜈𝜇 disappearance modes will be dominated by systematic uncertainties. To reduce these uncertainties to discovery-level precision, an Intermediate Water Cherenkov Detector (IWCD) is introduced at a distance of … Lire la suite
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2012 — Stratigraphic architecture and facies analysis of the Lower Cretaceous Dina Member of the Mannville Group in Northwest Saskatchewan.Résumé
The Dina Member in northwest Saskatchewan was deposited unconformably on top of the underlying Devonian Elk Point Group with the thickest Dina sandstones residing within paleo-topographic lows on the unconformity surface. The Dina Member was extensively eroded by Pleistocene glacial processes and is unconformably overlain by Pleistocene glacial tills. Analysis of 83 stratigraphic test hole drill cores and 255 geophysical well log suites has revealed 8 recurring facies and 5 facies associations. The facies are comprised of siliciclastic sediments, including sandstones, siltstones, mudstones and in rare instances, coal. These facies are predominantly non-marine in origin, including fluvial sediments and associated … Lire la suite
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2022 — The effect of relapsing-remitting Multiple Sclerosis on gait variability and regularityRésumé
Multiple Sclerosis (MS) is an inflammatory and neurodegenerative autoimmune disease that destroys the myelin sheath of the central nervous system. Gait impairments are one of the most debilitating and concerning symptoms for PwMS that can significantly impact an individual’s quality of life. Gait changes in people with MS (PwMS) have often been quantified using basic spatiotemporal parameters; however, research into more complex measures of gait variability, such as the measurement of small fluctuations that occur during the gait cycle (e.g., fractal-scaling index (FSI)), and the measurement of the consistency of trunk-based acceleration waveforms (gait regularity), have been shown to provide … Lire la suite
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2015 — Evaluation of Environmental performance of Hypothetical Canadian Oxy-Fuel Combustion Carbon Capture with Risk and Cost AnalysesRésumé
For at least the next few decades, fossil fuels will be used to supply energy globally, and without appropriate greenhouse gas control techniques, carbon dioxide (CO2) atmospheric emissions will continue to increase and pose an even more serious threat to humans and their environment. Therefore, the use of an effective CO2 capture technology has become important in ensuring the reduction of CO2 emissions. However, more raw materials and energy are required for the CO2 capture systems operation. Consequently, it is necessary to evaluate the environmental performance of the complete life cycle of the CO2 capture process in order to fully … Lire la suite
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2016 — A Qualitative Exploration of Doctor-Patient Relationship Experiences in Trauma Survivors and Primary Care PhysiciansRésumé
The Diagnostic Statistical Manual of Mental Disorders, fifth edition, defines trauma as “any event or events that may cause or threaten death, serious injury, or sexual violence to an individual, or his or her close family member or close friend” (American Psychiatric Association, 2013, p. 830). As a result of trauma exposure, there may be a change in the ways survivors think, behave, and relate to others. Survivors’ ability to trust others may be distorted such that they may be unwilling to trust others, including professionals who can provide help. Trauma survivors are also at risk for developing multiple medical … Lire la suite
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2020 — A Patient Oriented Research Approach To Assessing Patients’ And Primary Care Physicians’ Opinions on Trauma-Informed Care in Primary Care in CanadaRésumé
Trauma-informed care (TIC) is understanding and responding to the impact of trauma, while promoting safety, trust, collaboration, empowerment, peer support, and cultural sensitivity. While there are two commonly cited models (Elliott et al., 2005; M. Harris & Fallot, 2001), there has been no standard way of conceptualizing or operationalizing TIC in healthcare. Although past studies (B. L. Green et al., 2015; Miller et al., 2017; Schiff et al., 2017) have investigated training healthcare providers on TIC, outcomes for these studies focused mainly on providers’ feedback of the training program. To date, no study has asked providers how much they practice … Lire la suite
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2020 — Tales of Re-Entry to Adult High School Programs: A Rhizomatic (De)(Re)TanglingRésumé
This rhizomatic research is an experimental wondering and wandering with a Deleuzian- Guattarian mindset. The purpose of this study is to de-re-territorialize affective adults who have been dropping out and dropping back in to high school. Adults who are dropping out and dropping in often find themselves placed at society’s margins. These margins occur outside of the (ir)rational system of education that purposes to shape its body of students, its product, its graduates, through the attainment of a high school diploma. The re-entry (dropping in) process is the focus in this study. Thus, attention is given to possible (re)consideration of … Lire la suite
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2018 — EV Battery Wear Cost Optimization for Frequency Regulation Support in a V2G EnvironmentRésumé
In addition to improving the ground transport and the environment through reduced greenhouse gas emissions, Electric vehicles (EVs) can support a number of power grid services through the Vehicle to Grid (V2G) system. If EVs charging and discharging are properly integrated and managed, they can be grouped to provide ancillary services like Frequency Regulation (FR), peak load leveling etc. Proper integration of EVs can help in integrating renewable energy sources and provide various demand response. There are a number of challenges that should be addressed before EVs can effectively provide these services. The main challenge is the availability of power … Lire la suite
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2018 — Poised for Change: Saskatchewan Undergraduate Social Work Students' Understanding of the EnvironmentRésumé
Saskatchewan undergraduate social work students’ understanding of the environment and its relationship to Social work has primarily applied a person-in-environment framework to practice, which has evolved to almost exclusively mean the social environment. However, with the growing environmental crisis, social work can no longer ignore the natural environment and the impact it has on individuals and communities as well as the degradation of the environment itself. Despite the dearth of information on how to incorporate the physical and natural environment into social work practice, the literature beseeches social workers to address environmental concerns and issues. The research question within this … Lire la suite
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2018 — A Politics of Inwardness: Rousseau and Kierkegaard in DialogueRésumé
This thesis draws out some political implications of Kierkegaard’s concepts of faith, identity, and ethics. It does so by positioning Kierkegaard alongside Rousseau, whose work evinces a conflict over whether a good person can also be a good citizen. Via Rousseau, Kierkegaard’s religious individual is examined from a political perspective, putting in a new light some of the concerns that Kierkegaard’s believer is unsuitable and even noxious to political life. Kierkegaard’s own critique of Rousseau’s ideal citizen as amoral is then posited as a reason to reject Rousseau’s citizen as an alternative to the life of faith. Finally, Kierkegaard’s believer … Lire la suite
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2021 — Mother Tree Optimization for Solving Continuous and Discrete Optimization ProblemsRésumé
Continuous and discrete optimization problems play a signi cant role in di erent academic and industrial disciplines. The main objective of a constraint optimization process is to nd a solution for a problem, that satis es a set of constraints while optimizing a given objective function. The exact or mathematical methods can guarantee the solution if one exists; however, these methods su er from their exponential time cost. Thus, metaheuristic methods have been introduced as e cient approximation approaches for solving real-world optimization problems in a reasonable time frame. In addition, there are always new hard problems that need a … Lire la suite
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2025 — Developing photoresponsive lipid nanoparticles for the triggered release of small moleculesRésumé
This thesis will examine numerous photo responsive drug delivery nanoparticles containing two different first-generation (1G) donor-acceptor Stenhouse adduct (DASA) molecules, DOPC, DLPC, cholesterol and lauric acid. The DASA isomerizes upon visible light irradiation, thereby increasing membrane permeability through disruption of the bilayer and releasing cargo. A 1G dioctyl DASA and a new 1G cholesterol-DASA conjugate were synthesized, and their photophysical properties were studied and compared. The dioctyl DASA was studied in DLPC with and without lauric acid, as it was observed that the lauric acid promotes thermal isomerization of the photochrome, eliminating photocontrol of the system. Thus, the incorporation of … Lire la suite
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2021 — Investigating the Relationship Between Problematic Smartphone Use, Intolerance of Uncertainty, And MindfulnessRésumé
Problematic smartphone use (PSU) describes subjective distress, impairment, and/or negative consequences in important areas of functioning due to an inability to regulate smartphone usage (Billieux, 2012; Merlo et al., 2013). PSU is correlated with several mental health concerns, including symptoms of depression, anxiety, and perceived stress (Demirci et al., 2015; Elhai et al., 2017; Elhai et al., 2019; Samaha et al., 2016). Intolerance of uncertainty (IU) is related to numerous anxiety-related disorders (Carleton 2016a, 2016b) and may be a transdiagnostic cognitive mechanism relevant to PSU. A statistically significant increase in IU and smartphone usage from 1999 to 2014 suggests a … Lire la suite
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2016 — "Thrice-Male...Thrice-Powerful": Gender and Authority in Apocryphon of JohnRésumé
The following paper examines Apocryphon of John through two different analytic frameworks that make this complex and at times, seemingly bizarre 2nd century C.E. Egyptian text intelligible: (Middle) Platonism and gender. First, the text is analyzed in continuity with the ideological content and rhetorical strategies of contemporary Middle Platonic literature. Next, the text is analyzed as a gendered piece of literature, with attention paid to the rhetorical usefulness of gender in deploying motifs of femininity, masculinity, and androgyny in Apocryphon of John and other contemporary literature. Each mode of analysis shows how Apocryphon of John sets up an oppositional narrative … Lire la suite
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2019 — "Big Damn Heroes": Zoe Washburn and the Evolution of the Warrior Women in FireflyRésumé
This thesis explores the evolution of science fiction television in the United States alongside the disruption of the third wave of feminism as a result of the turn to patriotism and nationalism following the September 11, 2001 terrorist attacks. Specifically, I look at the subgenre of space opera, examining how presentations of women characters have changed throughout the subgenre’s history. Where women once occupied juvenile roles such as a damsel in distress, as is the case in Captain Video and His Video Rangers (1949-1955) and Tom Corbet, Space Cadet (1950-1955), they now embody more complex and multifaceted characters. I specifically … Lire la suite
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2013 — Prenatal Testosterone, Empathy, Emotion Recognition, and Facial Mimicry in WomenRésumé
This study examined whether individual differences in facial mimicry, emotion recognition, and empathy are related to prenatal testosterone (PT) exposure. Previous studies have found relationships among facial mimicry, emotion recognition, and selfreport empathy scores; further, imaging studies suggest that mimicry, emotion recognition, and empathy have shared neural bases. Previous evidence also suggests that the development of some of these shared brain regions is influenced by prenatal sex hormones (Goldstein et al., 2001), and a recent study demonstrated that exogenous testosterone administration decreases facial mimicry in women (Hermans, Putman, & van Honk, 2006). The present study examined the relationships among PT … Lire la suite