McGill University Thèses et mémoires par auteur commençant par T

The temperate bacteriophages Mu and D108 catalyze and regulate the transposition of their 37 kb genomes through several specific protein-DNA interactions. Two early phage encoded gene products directly involved in this process include the transposase (gene A) and ner proteins. We have cloned, overexpressed and visualized the ner proteins of both phages under the control of the lac UV5 transcriptional promoter and determined (using the band competition assay) that each is a site specific DNA-binding protein. We also physically mapped these ner operator sites by DNase I-footprinting and found minor DNA sequence conservation. Analysis of the DNA sequence of the …  Read more

The efforts towards the international unification of air law have been carried on since the Age of Aviation began. In 1911, the Comité Juridique International d'Aviation presented the first suggestion of a uniform law, the Code International de l'Air. International conferences and conventions have contributed to the partial unification of some rules in international air navigation. Many writers in this field have emphasized the convenience of a broader unity.  Read more

Ce mémoire examine deux grands projets d'infrastructure énergétique et logistique du nord-ouest de la Colombie-Britannique, la Northwest Transmission Line et le Stewart World Port. À partir d'évaluations environnementales, de rapports gouvernementaux, de publications d'ingénierie, d'articles de journaux, de films, de photos, de cartes géographiques et de matériaux divers, il explore comment ces deux structures affectent la géographie matérielle de l'activité minière dans la région en traçant leur histoire, leur héritage et leurs formes contemporaines. Le premier chapitre étudie le contexte politique de la construction de la ligne de transmission en relation à l'histoire coloniale de la région, une histoire motivée …  Read more

Cette thèse examine comment les technologies médiatiques et le développement d’infrastructures sont utilisés pour transformer et maintenir les rivages urbains et les voies navigables du port de Vancouver en un milieu logistique. Terminal Infrastructure: Port Authority and the Making of a Logistical Milieu analyse l’essor de la logistique comme stratégie clé des efforts étatiques et capitalistes pour gérer le territoire, dans un contexte toujours actuel de dépossession coloniale et d'extractivisme. Cette étude se consacre au port de Vancouver en tant que site phare où cette stratégie est mise en œuvre et explore la manière dont la domination coloniale et capitaliste …  Read more

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibodies to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. Beta2GPI-reactive T cells have been shown to be activated in patients with APS, but the mechanism responsible for this activation remains unclear. Recent studies have proposed that exposure of a cryptic epitope on beta2GPI, as a consequence of binding to PL, leads to the activation of beta2GPI-autoreactive T cells in APS patients. To test this hypothesis, we evaluated the development of beta2GPI-reactive T cells in a murine model of …  Read more

This thesis investigates data aggregation techniques for low power, distributed wireless networks. Nodes in such networks are constrained in terms of processing power, cost, networking performance, and available energy which makes the transmission of all generated data impractical. Additionally, the sensitive nature of data collected by the networks and physical vulnerability of nodes suggests that end-to-end encryption needs to be used in order to maintain security. The strict security constraints pose challenges in aggregation and routing algorithm design, due to the complexity-security trade off in distributed computing. Information must be shared between nodes in order to calculate meaningful results while …  Read more

Parker, William A. (Internal/Supervisor)  Read more

Le mixage multi-pistes est un processus itératif dans lequel divers paramètres de traitement, tels que l'équilibre de sonie, l'égalisation et la compression sont ajustés pour obtenir un signal de sortie cible conforme à des critères perceptifs et objectifs. La recherche sur les systèmes de mixage automatiques a connu une croissance rapide au cours des dix dernières années, proposant des systèmes intelligents pour presque tous les aspects de la production audio. Des outils intelligents analysant les liens entre tous les canaux audio afin d’en automatiser leur mélange ont été conçus. Dans cette recherche nous étudions, développons et mettons en œuvre des …  Read more

Popovich, Milica (Supervisor2)  Read more

Rationale: Risk assessment tools are frequently used to help surgeons and patients decide whether the potential benefits of cardiac surgery outweigh the risks. One of the most popular risk estimation tools, the 2000 Parsonnet score, has shown varying levels of predictive ability in different regions throughout the world. This risk estimation tool is based on 37 variables. According to the literature, institutional quality, medical personnel and patient ethnicity also have predictive value when measuring the risk of in-hospital mortality yet these are not included as risk factors in the model. It is hypothesized that a regional score based on the …  Read more

Research with 2SLGBTQIA+ communities is a growing domain of interest in Canada (MHCC, 2012), yet, still considered inadequate (Waite & Denier, 2019). Research on mental health, for instance, is robust in the description of the characteristics of mental health across these populations (Filice & Meyer, 2018; Kidd et al., 2016; McIntyre et al., 2011; Veltman & Chaimowitz, 2014); however, there are insufficient initiatives investigating the kinds of care and treatment that would best serve these communities (Pachankis et al., 2022). 2SLGBTQIA+ populations are known to be negatively affected by stigma and discrimination, which impact mental health outcomes and treatment access …  Read more

Le syndrome métabolique (SMet) est une préoccupation importante des pays industrialisés au niveau de la santé publique. SMet est un groupe de troubles métaboliques, qui comprend l'obésité abdominale, la dyslipidémie athérogènique, l'hypertension artérielle, la résistance à l'insuline et la présence d'un état pro-inflammatoire et pro-thrombotique. Actuellement, il n'existe aucune intervention thérapeutique efficace pour la prévention et le traitement de ce syndrome. L'inflammation systémique chronique et l'hypercholestérolémie sont deux cibles thérapeutiques importantes du SMet. Le but de cette recherche est de développer une nouvelle formulation biothérapeutique de microcapsules probiotiques produisant de l'acide férulique pour combattre le SMet. En particulier, des souches …  Read more

Anthropological classics such as E. H. Man's On the Aboriginal Inhabitants of the Andaman Islands (1883) and A. R. Radcliffe-Brown's The Andaman Islanders (1922) are generally regarded as products of an emergent nineteenth century social science. These anthropological classics were accepted by contemporaries as authoritative statements in their authors' fields of competence, and the ethnographic 'pictures' of the aborigines they presented were accepted as accurate descriptions of indigenous life. The following thesis argues for an alternative approach to the history of the production of anthropological knowledge. It begins by exploring the gradual codification of observational practices in the nineteenth century …  Read more

Les jeunes ayant des problèmes de conduite pendant l’enfance courent un risque accru de problèmes de santé tout au long de leur vie. L’une des conséquences bien documentées est une utilisation accrue des services médicaux à l’âge adulte. Bien que des données émergentes suggèrent que les adolescents ayant des antécédents de problèmes de conduite ont davantage recours aux services médicaux, des lacunes importantes subsistent dans la compréhension des mécanismes à l'origine de cette association. L'une des explications possibles réside dans les comportements néfastes pour la santé, tels que les troubles du sommeil. Le sommeil est un comportement essentiel au bien-être …  Read more

The synthesis of nucleosides (28a) and (28b) is described.* The best procedure consisted of a five step synthesis from 5-methyluridine. Simultaneous protection of the 3'- and 5' -hydroxyl groups of 5-methyluridine with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane-1,3-diyl gave nucleoside (11). Base protection of nucleoside (11 ) with (trimethylsilyl)ethoxymethyl chloride provided product ( 24). It was transformed to its allyl ether (23) by reaction with allyl bromide and silver (11) oxide. Oxidation of ( 23) with N-methylmorpholine N-oxide and osmium tetroxide, followed by sodium metaperiodate afforded aldehyde (27). Desilylation of aldehyde (27) gave the desired nucleosides (28a) and (28b).* 1H-NMR analysis of the diacetylated forms …  Read more

Dudley, Roy William (Internal/Cosupervisor2)  Read more

This thesis is an overview of the historical context in which the church of Christ the Redeemer (Sant'Apollinare Nuovo) in Ravenna, Italy, was erected. It explores the forces responsible for shaping the church at the time of its construction and decoration in the sixth century. The basilica had gained popularity of usage as a model for the Christian Church in the West by this time. This thesis further explores the conclusions put forth by scholars that the basilica was the forum in which the transition of architectural imperial symbolism from the pagan empire to the new Christian Church took place, …  Read more

Several different socioecological models have been developed to better understand the social organisation of various primate taxa. This thesis addresses two points of divergence between empirically observed behaviour and that predicted by current models for folivorous (leaf-eating) primates. First, many folivores form small groups despite the assumed low food competition among folivorous primates that would theoretically eliminate a key constraint on group size. This phenomenon is termed the folivore paradox since the small groups that they form have fewer anti-predator and anti-infanticidal advantages than do large groups. Second, defined dominance hierarchies are not expected to occur among females in a …  Read more

Jaksic, Vojkan (Internal/Supervisor)  Read more

Aujourd’hui, la majorité de la production chimique industrielle repose sur des processus catalytiques, plus écologiques et économiques que les méthodes stœchiométriques classiques. L’utilisation de catalyseurs organométalliques donne accès à de nombreuses réactions chimiques complexes grâce à la capacité des métaux de transitions à activer les molécules organiques. Cependant, même des quantités catalytiques de métaux posent de sérieux problèmes environnementaux. Le début du 21ième siècle a été marqué par l’utilisation de plus en plus répandue de biocatalyseurs dans l’industrie afin de remplacer les catalyseurs métalliques et organométalliques. Ces biocatalyseurs sont des machines biologiques fascinantes, capables d’effectuer des réactions chimiques difficiles, très …  Read more

On définit d'abord la catégorie dérivée d'une catégorie abélienne quelconque et ensuite on étudie le cas particulier de la catégorie dérivée bornée des faisceaux cohérents sur une courbe projective non-singulière.  Read more

On commence avec la généralisation du résultat de Kaledin et Verbitsky que les espaces twistoriels des variétés hyperkählériennes admettent des métriques semi-kählériennes. On démontre qu'en fait l'espace twistoriel d'une variété hypercomplexe compacte quelconque est semi-kählérien. On étudie ensuite des fibrés vectoriels holomorphes sur l'espace twistoriel d'une variété hyperkählérienne simple et la stabilité de leurs restrictions aux fibres de la projection twistorielle holomorphe. On démontre, en étendant un argument de Teleman, que la stabilité et la semi-stabilité des restrictions aux fibres d'un fibré sur l'espace twistoriel sont des conditions ouvertes de Zariski sur la base de la projection twistorielle holomorphe. On …  Read more

Scientistic authors in the latter half of the 19 th century and the early 20th century, such as Ernest Renan and H. G. Wells, discounted revealed religion. Yet they believed in the secular myth of an imminent technological Eden and they elevated science itself to the dignity of a religion. In so doing, they shaped bold visions of the future, drawing heavily on a millenary store of Western myth and metaphor. In historical terms, the myth of an imminent technological Eden represents a survival and a fusion of the ancient Greek myth of the Golden Age along with three Judeo-Christian …  Read more

During the Italian Renaissance, artists and anatomists compared man to various mechanical devices, in an attempt to uncover knowledge about the structure and processes of the human body. In so doing, they drew on ancient Greek notions of instrumentality and proportion. During the early Scientific Revolution, the metaphor of Man the machine played a key role in the development of mechanistic philosophy. During the Enlightenment, it served views on materialism and atheism. By the nineteenth century, when the Industrial Revolution was in full swing, a fundamental change in the relationship of man to machine had come about. Whereas, for Protagoras, …  Read more

From time immemorial the River st. Lawrenae has been the natural gateway of North America. Nearly four hundred years ago, Jacques Cartler sailed up the St. Lawrenoe until he reached Hochelaga, one thousand miles from the sea. A oentury passed, and the then deserted Hochelaga, lying at the foot of the Royal Mountain, became Maisonneuve's Montreal. Montreal owed its conception and birth to religious zeal. However perilous an outpost to the attacks of the Indians, it was admirably situatad as a mission at the Junation of two great rivers, the St. Lawrenoe and the Ottawa, the key to a vast …  Read more

The lower members of the fatty acid series are quite conductive when they are dissolved in a material, like water, which has a high dielectric constant. Thwing (1) attempted to measure the entire range of binary mixtures of acetic acid in water but encountered considerable difficulty in making oapacitance measurement because of the conductance effect. Mixtures containing less than 30% acetic acid gave the most uncertain results. These dielectric constants were measured by the bridge method whioh is suitable for conductive materials. Dielectric constants of aqueous solutions of various electrolytes have been determined largely by the resonance and the Furth …  Read more

Laundering is a general term that comprises all the acts aiming at bringing back into circulation criminal funds, and especially drug trade benefits. So it became urgent to mobilize the financial and banking institutions into joining the repressive authorities' action. Thus the different states involved examined how the proceeds of crimes and offences linked to the sale of narcotics could be detected and identified. However the variations between all the national laws were likely to damage the fight that was getting itself better organized and internationalized. A true international crusade took place. Finally all the European and international authorities recommended …  Read more

The thesis examines the work of the media in Bosnia and Herzegovina in the post-war period and efforts to restructure its institutions and change journalistic practices. The main focus is placed the effort of the Organization of Security and Cooperation in Europe to facilitate "free and fair elections" in Bosnia and Herzegovina and the creation of the Media Experts Commission, which was to regulate the work of the media during this period. The difficulty that this Commission met during its work pointed to inadequacy of its mandate, as well as complexity of the issue of media transformation. The case of …  Read more

Commercial positron emission tomography scanners that use block detectors have additional blurring on spatial resolution, referred to as block effect. We studied the origin of the block effect, using experiments in which all other blurring effects were minimized and precisely determined. Bismuth germanate crystals (1 mm width) and a small (1 mm) 68Ge source were used to probe the spatial resolution of a CTI HR+ block detector and two precise translation stages to move detectors. Coincidence aperture functions for crystals in the block and for single crystals were compared. The central crystals in the block showed an additional blurring of …  Read more

This thesis examines constructions known as resultative constructions. In addition to the well-known adjectival resultative construction in English, I investigate the resultative V-V compound, found in Japanese, and the resultative serial verb construction, found in Edo. I propose a new classification of these constructions, which focuses on the argument structure of the construction. In Japanese resultative V-V compounds, the argument structure of a compound reflects the argument structure of the second verb only, while in Edo, the argument structure of the construction reflects the argument structure of both verbs involved. With this criterion, English resultative constructions are divided into two …  Read more

Common law in Canada recognizes the rights to self-determination and autonomy and the right of competent persons to decide for themselves on medical treatment which includes the right to refuse all treatment. The legal profession has caused Japanese law to begin to recognize these basic rights, however professional and societal factors combine to accord the Japanese physician a wide discretion to determine what information to disclose, especially in the case of cancer. This thesis examines the similarities and differences existing between Canada and Japan in the controversial area of informed consent and the patient's right to refuse treatment and as …  Read more

Some novel optical methods to study the structure of ordered latices have been developed. These methods, as well as the Bragg diffraction technique, have been used in rheo- and electro-optical studies of latex structure. In the rheo-optical studies, ordered latices were subjected to a simple shear field and a three-dimensional deformation of the structure was observed. The increase in spacing between parallel layers of particles is qualitatively explained by a proposed two-dimensional sliding layer model. In the electro-optical studies, ordered latices were subjected to an electric field and an asymmetrical particle distribution was found. The electric field effect was found …  Read more

La redondance cinématique est une caractéristique importante permettant aux tâches motrices d'être accomplies dans différentes situations, aussi appelée équivalence motrice, telles que lorsque des perturbations sont appliquées ou que des degrés de liberté (DL) supplémentaires sont imposés pendant la tâche. La capacité d'utiliser l'équivalence motrice lors des mouvements d'atteinte suite à un accident vasculaire cérébral (AVC) demeure inconnue. Cette thèse comprend une revue de littérature et trois études expérimentales. Le premier manuscrit propose une définition opérationnelle de la coordination interarticulaire et examine les mesures existantes de la coordination. Ce manuscrit illustre également l'écart de connaissance entre la pratique clinique et …  Read more

We examine whether the precepts of what have been termed 'close', 'intimate', or, more specifically, 'communal' relationships in Social Psychology may be communicated via Web site content and whether this positively impacts Site-Loyalty. We introduce a variable called Site-Communality defined as the extent to which Web site content signals that a company's relationship with its customers goes beyond the formal, 'tit for tat' business dealings that are typically expected from purely commercial exchanges, and instead, more closely abide by the norms and behaviours evocative of friendships and/or family relations. We develop multi-dimensional measures of Site-Communality and Site-Loyalty. Using Structural Equation …  Read more

The principle content of this thesis could be divided roughly into three parts: a) to establish some of the more imprtant theorems of the convex and subharmonic functions; b) to give a solution fof the Dirichlet Problem for the circle which, as we will see, is essenstial in the development of the theory of subharmonic fuctions; c) to show the analogy existing between the theories of the convex and subharmonic functions. Historically the first elementary and systematic expostion of convex functions was written by J. Jensen in 1906. Of the many authors who, following Jensen, have developed the theory in …  Read more

The author of this study has for sorne time been interested in the status and history of education in Canada as a whole. As a teacher, he has been acutely aware of his ignorance of what goes on in the schools of other provinces, and has been curious to learn what external and historical forces have helped to shape whatever pattern of education Canada can be said to possess. Part of his ignorance was dispelled and some of his curiosity satisfied in doing graduate research on the history of education in Canada. Part of this research involved a consideration of …  Read more

Radiation therapy of the thorax may result in side effects such as alve- olitis and pulmonary fibrosis, both of which limit the efficacy of cancer therapy. Previously, it was determined that mice congenic on chromosomes 2, 4 and 11 succumb to radiation-induced lung disease significantly faster than C57BL/6J mice. Herein we use chromosome 4 and 11 congenic strains and chromosome 4 sub-congenic strains to identify radiation-induced lung response susceptibility loci in C3H/HeJ congenic mice on a C57BL/6J background. Mice were treated with 18-Gy whole-thorax irradiation and their survival, lung histopathology, and BAL cell types were determined. All protein coding genes …  Read more

Cette thèse examine le marché du voyage de l'espace commercial et examine le droit de l'espace s'y rapportant. Un examen des lacunes dans le droit international de l'espace est réalisé avec la conclusion que le droit international de l'espace manque lorsque l'industrie se développe. Le régime de responsabilité, en particulier, est manquant certains aspects qui aideront l'industrie à décoller vers la rentabilité. Le coût de voyage de l'espace commercial est actuellement très élevé. Il est proposé qu'une limitation de responsabilité, tels que les limitations imposées à l'industrie de l'aviation, permettront aux opérateurs de programmes du voyage de l'espace commercial et …  Read more

Lignin is unquestionably one of the most baffling of the naturally occurring organic substances that has attracted the attention of the chemist. Occurring as it does in all woody plants, in grasses, cereals and so forth, and to the extent of about 30% in coniferous trees, it is one of the most abundant of raw materials. Unlike cellulose and rubber, lignin has found no application in industry and the arts. rhus quite apart from the academic interest, the study of the structure of lignin implies an endeavour to find some means for its utilization. [...]  Read more

Fluid flow has been measured through almost every type of porous material. A considerable portion of these permeability studies has been directed towards the flow of gases through a bed of charcoal grains. The interest in gas flow through charcoal arises from the ability of charcoal to separate one gas from another, and this property has been widely applied both in chemical warfare and industry. It is of fundamental importance to the knowledge of gas flow through a bed of charcoal grains to understand the process by which the sorbable gas is carried into the interior of the charcoal grain. …  Read more

Arguments concerning the nature and extent of the North American glaciation as a whole, and that of Labrador in particular, have been regularly appearing in print from 1883 until 1959. From the theories and reports presented it is possible to draw together several distinct lines of thought. Early work by Bell (1882-84), Daly (1902), and Coleman (1921) suggested that the higher parts of the eastern edge of north east America had not been covered by continental ice. Coleman goes as far as to say that in the Nachvak area, “the unglaciated condition is known to reach at least 50 miles …  Read more

The library of Raymond Klibansky (1905-2005), historian of philosophy, was acquired by McGill University's Rare Books and Special Collections in 2005. This first study of the Raymond Klibansky Collection (RKC) provides an introduction to the approximately 7000-title collection in its main characteristics and research strengths; offers an aid to further research on the collection; and builds on what is known about Klibansky and his life with books. The approach to the study was developed from a review of methods proposed in current discussion of book and library history research, and from structures and themes observed in practice in related studies. …  Read more

In response to consumer trends, conventional synthetic food additives used to control the growth of foodborne bacterial pathogens are being replaced with natural alternatives. Bacteriophages (phages) are viruses of bacteria that have been successfully applied in the control of pathogenic bacteria in food. Cocktails of virulent phages have been designed for exogenous application to specifically target individual bacterial species that are of public health concern. One disadvantage to this approach is the fact that multiple bacterial species can cause foodborne illnesses or food spoilage, and phage cocktails are unable to control multiple bacterial species. An alternative phage-based method that involves …  Read more

Ectogenesis -- literally creation outside the womb -- is a word coined by British geneticist J.B.S. Haldane in 1923 as he provocatively predicted future scientific frontiers. Fast-moving assisted reproductive technologies assure us that ectogenesis is no longer the fantastical creation of futuristic writers. Instead, it is likely to manifest in one of three ways. It may be a quiet byproduct of the lessening gap between in vitro procedures and the use of sophisticated neonatal environments. It may arise from endometrial tissue ladders grown into artificial wombs. Or, it may be as bizarre as that envisioned in Brave New World where …  Read more

The shell theory of nuclear structure is based on the assumption that there is an average attractive potential acting on a nucleon as it travels within the nucleus. The ground state of a nucleus zXan is then constructed by consecutively filling the lowest available levels of the potential well with Z protons and N neutrons in a manner consistent with the Pauli principle. Mayer and Jensen demonstrated that a considerable body of data could be understood in terms of this model if one included in the potential a spinorbit term. For example the magic numbers and the ground state spins …  Read more