McGill University Thèses et mémoires par auteur commençant par T

Extensive church building programmes and the relocation of existing churches were important features of Protestant congregational life in industrializing cities across Britain and North America. In Montreal, building booms in the 1860s, 70s, and 80s led many congregations to abandon their old churches in the centre of the city and rebuild on a grander scale 'uptown', closer to the residential neighbourhoods to which their wealthier members were moving. In the early twentieth century, when a new phase of growth engulfed the city, many of the same congregations again faced the dilemma of whether or not to move. Whereas the earlier …  Lire la suite

This work focuses on the efforts of Montreal's Irish Catholics to maintain a cohesive ethnic community throughout the nineteenth century, and on the vital role that the national parish played in this process. The early community directed its attention towards institution building centred around Saint Patrick's church, which had been built for the use of Irish Catholics in the 1840s. Following the dismemberment of the extensive parish of Notre-Dame and the erection of smaller Irish national parishes in the early 1870s, greater emphasis was placed on the creation of a wide variety of parish societies. By discouraging participation in Irish …  Lire la suite

The two most common forms of dementia, vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD), display substantial similarities with regards to their cerebrovascular pathology and they share cardiovascular risk factors as predictors of future cognitive decline. These commonalities suggest that it may be possible to prevent, alleviate and potentially treat both forms of dementia by targeting the cerebrovasculature. Presented in this thesis are findings pertaining to how the pleiotropic effects of the anti-cholesterol drug simvastatin (SV) and, regular, moderate levels of aerobic physical exercise (EX) can prevent VCID. While investigating the commonalities between these two treatment approaches, we …  Lire la suite

In Canada, the control of relative humidity is a key issue in greenhouse production as it has a direct and significant effect on dehumidification cost, crop quality and yield. Experiments were carried out to measure plant transpiration rate and fruit yield under four different ambient water vapour pressure deficits. Four identical greenhouses were used to produce tomatoes (Lycopersicon esculentum Mill.) under four different regimes of water vapour pressure deficit (VPD). Dehumidification costs were highly correlated to VPD: low VPD produced low transpiration requiring little dehumidification. Thus, managing plant transpiration can lead to a more efficient use of transpiration for crop …  Lire la suite

Telomerase is the major mechanism that compensates for telomere loss during conventional DNA replication in eukaryotic cells. This enzyme is a ribonucleoprotein reverse transcriptase, composed of an RNA subunit (TR) containing a template that dictates the telomeric DNA sequence, a catalytic subunit (TERT), and others associated proteins. In order to characterize the telomerase RNA-proteins interactions in two different organisms, Tetrahymena thermophila and human, we developed two electrophoretic RNA mobility shift assays. In Tetrahymena, we identified a specific RNA-protein complex by using whole cell extracts partially purified and in vitro transcribed and radiolabeled Tetrahymena telomerase RNA (159 nt). Certain Tetrahymena telomerase …  Lire la suite

Adrenals from adult male mice, when incubated in Krebs-Ringer bicarbonate glucose solution, produce corticosterone, aldosterone, and a polar lipid with the properties of 18-hydroxycorticosterone; the polar fraction also contains other reducing lipids. [...]  Lire la suite

Une méthode perfectionnée de fractionnement des glycosaminoglycanes a été mise au point et appliquée à l'étude des glycosaminoglycanes aortiques au cours de l'artériosclérose, du diabète et du vieillissement. L'artériosclérose induite par le cholestérol chez les jeunes lapins non-diabètiques est caractérisée par une diminution de la teneur en acide hyaluronique et une augmentation en sulfate de chondroïtine. L'aorte normale de lapins agés a une teneur en glycosaminoglycanes comparable à celle de jeunes aortes malades; aucune autre modification a été observée dans lès aortes agées. Le (U-l4C) glucose s'incorpore, in vitro, plus dans l'acide hyaluronique que dans les glycosaminoglycanes sulfatés des aortes …  Lire la suite

This thesis addresses the problems related to the assessment of gender-based claims of persecution under the international definition of 'refugee'. The 1951 United Nations Convention Relating to the Status of Refugees does not list 'gender' as one of the persecution grounds that entitle a person to seek refuge. In attempting to solve this apparent dilemma, the 'membership of a particular social group' category was long considered to be the appropriate assessment framework. While nowadays the other four enumerated Convention grounds---race, religion, nationality, and political opinion---have increasingly received regard, the approach to gender-based persecution has so far been neither systematic, nor …  Lire la suite

L'éducation à la sexualité prend un tournant innovateur en forgeant des partenariats entre les écoles et des organismes communautaires. Les évaluations du Projet Sens, un programme issue d'un organisme communautaire situé à Montréal, indiquent que les jeunes répondent avec enthousiasme à cette initiative. Ces partenariats, cependant, doivent naviguer a travers les mêmes tensions epistemologiques et culturelles se produisant partout alors que nous redéfinissons collectivement les savoirs entourant le corps, les sexualités, et l'identité des jeunes. Dans la première phase de cette étude, des étudiants ayant prit des cours d'éducation a la sexualité réfléchissent sur leurs expériences. L'étude identifie le contenu …  Lire la suite

As sexualities educators, we rarely examine the broader social context our sexualities are shaped within, nor do we often give meaningful instruction to students on how to come to terms with emotions and desire or choosing and being good partners. Some of the ways we 'do' masculinity, femininity and gender in this culture can compromise our ability to fully engage in loving relationships with our selves and others. Teaching sexualities as transformational learning, critical theory challenges us to do better, both as individuals and as a society aware of and resisting oppression. Instead of teaching as though the body and …  Lire la suite

This paper examines the tensions resulting from multiculturalism's quest to achieve equality through the recognition of cultural difference. The author argues that multiculturalism is inherently limited in its potential to recognize deep difference because it operates through the framework of the conceptual heritage of the Enlightenment's political project. Multiculturalism's dependence on Enlightenment evaluative norms means that difference and diversity can be recognized to the extent that they further the objective of achieving liberty and equality for all. The author examines the theoretical legacy of the Enlightenment as it informs the multicultural project and also analyses the impact of poststructuralist theory …  Lire la suite

In the Socialist Republic of Vietnam, state policies governing land use, market integration, and poverty reduction largely determine the prospects for social-ecological resilience. In turn, land system change in the northern uplands has largely been shaped by market liberalization and the integration of ethnic minority farmers into state development practices and ideologies. Hybrid crops and plantation forestry are increasingly being adopted with important implications for local livelihoods and ecosystems, although the long-term outcomes of such land changes remain poorly understood. The aim of this thesis is to explore the relationships between state policy, land use change, and social-ecological resilience from …  Lire la suite

The biological degradation of the synthetic aliphatic/aromatic co-polyester Ecoflex(TM) (BASF) by 30 strains of hydrolase-producing soil bacteria, fungi and yeasts was investigated at moderate environmental conditions. Previous studies had shown that these materials could be degraded. These studies were done uniquely in compost or by axenic compost isolates, and under thermophilic conditions, but it is likely that most of this material will be found in sites at more moderate conditions. Thus, a screening procedure was developed to assess the biodegradability of the co-polyester at ambient environmental conditions. The screening also allowed for the investigation of the mechanism of biodegradation in …  Lire la suite

Cette thèse vise à explorer les propriétés des Théories Conformes des Champs (TCCs) fortement couplées dans des espaces-temps à dimensions D > 2 en utilisant des méthodes modernes de « bootstrap » conforme. Nous commençons par détailler les propriétés fondamentales des TCCs, les méthodologies clés du « bootstrap » conforme, et les caractéristiques principales des deux TCCs fortement couplées considérées dans cette thèse : la théorie supersymétrique de Yang-Mills (sYM) à quatre supercharges en quatre dimensions ainsi que le modèle d’Ising en trois dimensions.Notre étude examine d’abord la fonction de corrélation à quatre points des opérateurs protégés avec une charge …  Lire la suite

Chan, Christopher (Internal/Cosupervisor2)  Lire la suite

DRR1 a été identifée comme un nouveau régulateur de l'invasion des cellules malignes gliales. Isolé à partir d'une étude de gènes surexprimés dans les cellules hyper-invasives, DRR est exprimé dans les régions périphériques de gliomes de haut grade [1]. En culture, les cellules DRR+ démontrent une invasion prononcée (dans les modèles collagène 3D et teste de migration 2D) et leur motilité est caractérisé par une morphologie allongée, mésenchymateuse avec des protrusions dynamiques.L'étude de l'invasion des cellules malignes est multi-facettes; un aspect de ce processus est la dysrégulation du remodelage du cytosquelette pour promouvoir la motilité. La remodelage du cytosquelette implique …  Lire la suite

L’ADN est un matériau exceptionnel pour l’assemblage par approche ascendante de nanostructures de formes arbitraires comportant un haut niveau de complexité grâce à sa nature programmable, prévisible et biocompatible. Une grande variété de structures d’ADN bien définies s’étalant de quelques nanomètres à plusieurs micromètres peut être construite avec un niveau de précision et de contrôle inégalé. Au-delà des perspectives qu’offre l’ADN en auto-assemblage, les chimistes ont découvert que les nanostructures en ADN offrent une excellente plateforme pour créer des réactions chimiques avec un haut niveau de sélectivité parce qu’il permet d’augmenter significativement la concentration locale des réactifs qui y sont …  Lire la suite

It has been argued that the principles of stimulus generalization (SG) derived from conditioning experiments also apply to human voluntary responses (e.g., Gibson, 1939; Brown, et al., 1951; Andreas, 1954; Mednick & Freedman, 1960). In order to prove this contention empirically, several experiments have been performed on a variety of voluntary responses, such as, verbal, perceptual, conceptual and judgmental. However, a critical survey of these studies, such as that reported in the following pages, reveals that they have failed to demonstrate convincingly any more than superficial similarities between their results and the results reported in conditioning experiments. Furthermore, their authors …  Lire la suite

In nonparametric testing based on ranks, the occurrence of ties is a fairly common phenomenon. Many methods have been suggested for assigning ranks to tied observations in such problems. In this thesis we review and discuss these methods with regards to their relative merits under different situations. The recent extension of the asymptotic theory of rank statistics from continuous to discontinuous distributions has made it possible to calculate the Asymptotic Relative Efficiency (ARE) of different methods of handling ties. A comparison, based on ARE, among the three main methods of handling ties, namely, the average scores, midranks and randomized ranks …  Lire la suite

Ninety-six child protection files were scrutinized according to the Holland Complex Care Case Review Data Collection Instrument in order to verify the applicability of the instrument to determined the variables influencing social workers in the determination of bringing an adolescent in need of protection into care. Results show that school related issues seem to influence workers in determining the need to remove the child from the family. Statistical analyses indicated numerous correlations supporting the link between case complexity and the need to bring an adolescent into care.  Lire la suite

Carnevale, Frank (Supervisor)  Lire la suite

Cette étude analyse les impacts de la politique d'aide étrangère des États-Unis sur la sécurité interne des États bénéficiaires. La documentation sur la sécurité internationale et les politiques conflictuelles m'a servi à développer une théorie sur l'effet coercitif de l'aide internationale. J'analyserai la manière dont l'aide étrangère des États-Unis affecte la capacité de gouverner des États bénéficiaires. J'analyserai particulièrement la capacité du gouvernement de l'État bénéficiaire d'employer la violence pour assurer la poursuite de son mandat. J'argumenterai qu'une des conséquences de la fongibilité – la capacité d'utiliser l'aide internationale comme une ressource gouvernementale – serait la possibilité d'augmentation de coercibilité …  Lire la suite

Omanovic, Sasha (Supervisor1)  Lire la suite

Propionaldehyde, isobutyraldehyde, trimethylacetaldehyde, and dibromacetaldehyde have been condensed with glycerol, the isomeric five and six membered glycerol acetals isolated in each case, and their structure and physical properties determined and compared with those of related compounds. The ratio in which the two isomers are formed from the different aldehydes has been carefully determined in each case and shown to depend to a marked degree, on the polarity of the aldehyde in question. The ease of glycerol cyclic acetal formation {total mixed glycerol acetal formation) is shown to decrease, with increase in the negative polarity of the aldehyde group, while the …  Lire la suite

Actin-based changes in filopodia dynamics and spine morphology play an important role in initiating synapse formation and mediating synaptic plasticity. During embryonic development, the guidance cue netrin-1 signals through Deleted in Colorectal Cancer (DCC) receptors to modulate actin cytoskeleton dynamics, enhancing the formation and motility of filopodia. We recently reported that netrin-1 and DCC continue to be expressed in the adult spinal cord, but their function remains elusive. Here, we report that netrin-1 and DCC are expressed in adult cortical and hippocampal neurons, where they distribute to synaptic sites. In primary cortical neuron cultures, while netrin-1 is restricted to dendrites, …  Lire la suite

Treg cells counter-balance autoreactive immune cells in healthy individuals. In the absence of Treg cells, multi-organ immune diseases manifest. Thus, Treg cell defects are suspected to contribute to T1D. Currently, it remains unclear whether Treg cell defects are responsible for the manifestation of T1D. Thus, we hypothesized that Treg cell defects results in T1D. We observed that T reg cells are present in normal frequencies in the thymus and peripheral immune system of diabetes-prone mice. Furthermore, thymic and peripheral T reg cells are operative and mediate regulation by suppressing effector T (Teff) cells in the pancreatic lymph nodes and pancreas. …  Lire la suite

Abstract not available.  Lire la suite

Le procédé Haber Bosch, utilisé pour la production d'ammoniac, attire beaucoup d'attention étant donné sa consommation énergétique élevée et son inefficacité. Cela a donc motivé les chercheurs à trouver une méthode alternative de production d'ammoniac. Cette thèse demaîtrise est une étude préliminaire d'un plasma non thermique à base d'azote à haute pression soutenu par des impulsions répétées de durée nanoseconde et serve à démontrer son utilisationpotentielle dans un procédé de production d'ammoniac.L'environnement hautement énergétique du plasma ainsi que la haute pression et la basse température forment les conditions nécessaires pour entraîner la formation d'ammoniac. Cette étude se concentre sur la …  Lire la suite

Azuelos, Ilan (Internal/Cosupervisor2)  Lire la suite

La protéine p53 est un gène suppresseur de tumeurs qui est muté dans plus de 50% des cancers humains. Quoique cette protéine soit étroitement contrôlée, elle peut être rapidement activée en réponse à une variété de stress cellulaires et mène à l'activation de plusieurs voies métaboliques telles que l'arrêt du cycle cellulaire, l'apoptose et la sénescence. p47 est un isoforme de p53 tronqué à l'extrémité N-terminale. La protéine p47 est générée soit par épissage alternatif de p53, soit par initiation de la traduction à un site alternatif, probablement par un mécanisme indépendant de la coiffe en 5' via un site …  Lire la suite

Alphonce, Bo (Supervisor)  Lire la suite

En réponse à la demande industrielle croissante pour les éléments du groupe des terres rares (ETR), l'exploration de la province alcaline de Colombie Britannique a récemment permis d'identifier la carbonatite de Wicheeda (11.3 millions de tonnes de minerai enrichi en terres rares légères, affichant une teneur de 1.95 % TREO (l'oxide des terres rares total) comme l'un des prospects de terres rares les plus prometteurs. Les précédentes investigations menées sur ce gisement se limitent aux rapports des compagnies ayant exploré la zone pour ses ressources potentielles en terres rares. La présente étude décrit la minéralisation en éléments des terres rares …  Lire la suite

Recently developed ultrasound contrast agents provide traditional ultrasound techniques with highly localized contrast within samples depending on contrast agent concentration. Contrast agents resonate at characteristic frequencies, allowing background signals in backscatter collected from samples to be easily removed through filtration, leaving only resonance from contrast agents remaining. The goal of this thesis was to develop analyte sensitive contrast agents based on molecularly imprinted poly(N-isopropylacrylamide) (pNIPA) nanogel polymers. Molecularly imprinted pNIPA was synthesized in presence of target analyte theophylline. Ultrasonic analysis of pNIPA behavior in the presence of varying theophylline concentration revealed amplitude changes at various frequencies. Analysis of chemically similar …  Lire la suite

Dumont, Marie-Josée (Supervisor2)  Lire la suite

Maureen D O'Connor-McCourt (Supervisor1)  Lire la suite

Post-poliomyelitis syndrome (PPS) is a clinical syndrome of new weakness, fatigue, and pain in individuals who have previously recovered from acute paralytic poliomyelitis. The primary objective of this study was to identify factors which predict subsequent PPS. Among patients with prior polio, cases were those with new weakness and fatigue, and controls were those without these complaints. A chart review of 353 patients evaluated at the Montreal Neurological Institute post-polio clinic identified 127 cases and 39 controls. In univariate analyses, significant risk factors for PPS were a greater current age (odds ratio of 1.8 per decade, 95% confidence interval 1.3 …  Lire la suite

Cette thèse est un rapport sur la conception, la construction et l'analyse des données du calorimètre hadronique digital (CALHD). Le CALHD a été construit dans le cadre des efforts menés par la collaboration CALICE pour la conception du détecteur SiD destiné au future Collisionneur Linéaire International (CLI). Le SiD est un des deux détecteurs proposés pour le CLI. Le CALHD lui-même n'est qu'un des sous-systèmes devant constituer le détecteur complet. La collaboration CALICE est impliquée dans le développement des calorimètres pour le CLI. Le CALHD utilise la technologie des chambers à plaques résistives pour détecter les événements physiques et est …  Lire la suite

The complexes CpRu(CO)$ sb2$SR(Cp = $ eta sp5$-cyclopentadienyl; R = 4-C$ sb6 rm H sb4$Me, C$ rm sb6H sb5, CH sb2C sb6H sb5$) insert sulfur from S$ sb8$ to give CpRu(CO)$ rm sb2S sb{x}$R (x = 1-3) and undergo ligand exchange with R$ rm sp prime sb2S sb{y}$ (y = 2,3) to give CpRu(CO)$ sb2 rm S sb{x}R sp prime$ (x = 1-3). The mechanisms of these reactions are discussed. Treatment of CpRu(CO)$ sb2$SH with the appropriate phthalimide sulfur transfer reagents REphth (phth = phthalimide; E = SS, SS(O); R = 4-C$ rm sb6H sb4Me, C sb6H sb5, CH sb2C …  Lire la suite

Menin, the product of the Multiple Endocrine Neoplasia Type 1 (MEN1) gene, is a widely expressed, predominantly nuclear protein that facilitates cell proliferation and differentiation control. In osteoblasts, menin has been shown to modulate osteoblast differentiation, an essential process for bone homeostasis. Our laboratory has initially established in vivo the importance of menin for proper functioning of the mature osteoblast and maintenance of bone mass in adult mice. In the current study, we seek to better understand the role that menin plays in vivo when expressed at earlier stages of the osteoblast lineage. To achieve this, conditional knockout mice in …  Lire la suite

Russell Davidson (Supervisor1)  Lire la suite

A model of faculty advising suggests that the tasks performed by faculty advisors are explained by three conceptual constructs differing in levels of complexity and type of skill. The three constructs identify a routine set of tasks termed Providing Information and two complex sets of tasks termed Developing Academic and Educational Goals, and Providing Personal Support. However, no empirical data exist to support this model. To test the model, a sample consisting of 481 University of Vermont undergraduate students rated their advisors on the three sets of items. The data were subjected to confirmatory factor analyses using maximum likelihood procedures …  Lire la suite

Full-fat soybeans require heat treatment to denature trypsin inhibitors which interfere with proper digestion of the soybean protein. This study examines the heat treatment of soybeans in a continuous particulate-medium conduction processor. Whole soybeans at 13% and 23% moisture were roasted at salt temperatures of 225, 250 and 275$ sp circ$C for residence times of 15, 30 and 60 seconds. The soybeans reached temperatures ranging from 107$ sp circ$C to 134$ sp circ$C, after which they were maintained in an insulated container for 0, 5, 10 or 15 minutes. Salt temperature, residence time, and moisture content were found to significantly …  Lire la suite

The parties to two modern agreements in Eeyou Istchee – the Crees of Eeyou Istchee and the Governments of Canada and Quebec – describe their treaty relationship in terms of a "new relationship" based on principles such as mutual recognition and reciprocity.Current perspectives on a new relationship in Eeyou Istchee are inadequate to understand the parties' complex normative interactions and political claims for recognition. An alternative paradigm is needed to conceptualize a new relationship, which emphasizes the political and legal processes that allow Aboriginal peoples and state actors to engage in reciprocal dialogue, and negotiate compromises to deep-seated normative disagreements. …  Lire la suite

Mackay, I. (Supervisors)  Lire la suite

The Imperial Conferenoe of 1926 was one of the outstanding events in world politios since the war. It might equally well be said that it was one of the most misunderstood. Many claimed that it destroyed the British Empire and established a new status for Great Britain and the Dominions - a status of full international independenoe, in which the only unity was the crown. This alleged result was alarming to all who believed in the empire, and a source of pride to all who harbored desires for its destruction. [...]  Lire la suite